MAX300-BIO Bioreactor/Fermentation Mass Spectrometer

Mass Spectrometry is a powerful tool for bioreactor monitoring. Changes to the composition of bioreactor or fermenter off-gas provide crucial insight into cellular health and production efficiency. This makes the fast, accurate analysis of CO2, O2, N2, Ar, H2O and other compounds essential for real-time process control. 

Extrel MAX300-BIO uses cutting edge quadrupole mass spectrometer technology to quantify bioreactor gases from multiple reactors within the facility and reports the data to the control system in real-time. 


  • Measures CO2, O2, N2, H2O, alcohols, contaminants, and more
  • Samples without risk of contamination
  • Calculates control parameters in real-time (e.g. Respiratory Quotient)
  • Provides flow and mass balance data
  • Multiport sample systems for up to 80+ reactors
  • High precision and accuracy for optimal process automation
  • Low maintenance, utilities and calibration required
  • Complete method scale-up
  • Lab, Pilot, Production


Industrial Bioreactors for
• Biofuels
• Ethanol
• Pharmaceutical Products
– Enzymes
– Antibiotics
– Steroids
– Vitamins
• Biomass
• Biopolymers
• Alcoholic Beverages
• Bread Products
• Waste Treatment

Measuring PrincipleQuadrupole Mass Spectrometer Technology
Detectable CompoundsAny Gas or Vapor Sample
Detection Range100% – 10 ppm Standard, 10 ppb with the Electron Multiplier Option*
*Documented on Trace Benzene in Air
Number of Sample Streams16, 31, 40, 80+
Analysis Rate< 0.4 Seconds Per Component
Number of ComponentsUnlimited
Number of Analysis RoutinesUnlimited
Number of User Configurable Data TagsUnlimited
Analysis Precision<0.25% Relative Standard Deviation**
** Based on the analysis of 1% Argon
Stability<0.5% Relative Standard Deviation Over 30 Days**
** Based on the analysis of 1% Argon
Dual FilamentsOne Active
One Spare with Automatic Switch Over
MaintenanceTypically Two PMs Per Year
Calibration and ValidationManual or Fully Automated
Mass Range Options1-200, 300 or 500 amu
Filter19mm High Transmission Quadrupole Filter
Power Supply110VAC, 50/60Hz, Two 15A Circuits
230VAC, 50/60Hz, One 20A Circuits
Power ConsumptionNominal: 2500 Watts
Startup: 2750 Watts
Heat Load: 2500 Watts (8000 BTU/h)
WeightStandard Enclosure: 190 Kg
ATEX Enclosure: 254 Kg
Optional Cart: 18 Kg
Ambient Temperature-20 ~ 49 deg C
With A/C, Cold Start >= 12 deg C
Area Classification OptionsGeneral Purpose
Class 1, Division 2 Groups B, C, D, T3
Class 1, Division 1 Groups B, C, D , T3
ATEX Zone 1 or Zone 2, Group II B +H2, T4
Additional UtilitiesPurge Gas (For Hazardous Area Installations)
Base Calibration Requirement: 2 Gas Bottles
Data System and CommunicationsSystem Control Interface Options: Ethernet, RS-422 (4 Wires)
Login Security Levels: Administrator, User and Viewer
External Communications:
Ethernet, Modbus Serial, Digital I/O, Analog I/O, OPC
A I ANALYTICAL PTE LTD | Address 30, Kallang Place, #06-01, Singapore 339159 | Tel: +65 6459 0785 | Email: